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KMID : 0355420010250020199
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Journal of Korean Academy of Oral Health
2001 Volume.25 No. 2 p.199 ~ p.206
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Effect of dentifrice containing Triclosan and Ursodesoxycholic acid on gingivitis and calculus formation
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Ma Deuk-Sang
Park Deok-Young
Lee Seung-Woo
Kim Johng-Bai
Paik Dai-Il
Moon Hyuck-Soo
Lee Jin-Wan
Kim Moon-Moo
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Abstract
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The aim of this study was to examine the effect of dentifrice containing 0.3% triclosan and 0.02% ursodesoxycholic acid(UDCA) on the reduction effect of gingivitis and calculus formation.
The study participants was composed of 70 women for examining gingivitis and 40 men and women for examining calculus formation.All participants were aged 20-24 years. Participants and investigators were blinded to group assignment and followed for 12 weeks on gingivitis and for 4 weeks on calculus formation.
We also investigated adsorbed/remaining concentration of triclosan of dentifrice dentifrice containing 0.3% triclosan and 0.02% UDCA on hydroxyapatite disk by laboratory study.
Obtained results were as follows:
1. Adsorbed concentration and remaining concentration of triclosan in dentifrice on hyroxyapatite disk was increased about 70% and 96% respectively by addition of UDCA(P (0.01).
2. After 12 weeks of use, gingivitis index was significantly reduced(P (0.05) among participants using dentifrice containing 0.3% triclosan and 0.02% UDCA while difference of gingivitis index of control group was not significant(P)0.05).
3. After 4 weeks of use, claculus formation was significantly reduced among participants using dentifrice containing 0.3% triclosan and 0.02% UDCA compared to the control group(P (0.05).
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KEYWORD
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Ursodesoxycholic acid, Triclosan
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